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Normal Lymphoid Tissues: Part 4

Massachusetts General Hospital

View larger version (161K): [in this window] [in a new window]   Figure 1. The spleen, located in the left upper abdomen, has two major compartments: the red pulp, which functions as a filter for particulate antigens and for the formed elements of the blood, and the white pulp, which is virtually identical in its compartments to the lymphoid tissue of the lymph node. Follicles and germinal centers are found in the Malpighian corpuscles, while T cells and IDC are found in the adjacent periarteriolar lymphoid sheath. Plasma cells accumulate in the red pulp. The white pulp has two components: the eccentric follicles (Malpighian corpuscles) seen here, and the periarteriolar lymphoid sheath seen in Figure 2. The follicles are identical to lymph node follicles (B cell zones), while the periarteriolar sheath is identical to lymph node paracortex (T cell zone).

View larger version (147K): [in this window] [in a new window]   Figure 2. The spleen, located in the left upper abdomen, has two major compartments: the red pulp, which functions as a filter for particulate antigens and for the formed elements of the blood, and the white pulp, which is virtually identical in its compartments to the lymphoid tissue of the lymph node. Follicles and germinal centers are found in the Malpighian corpuscles, while T cells and IDC are found in the adjacent periarteriolar lymphoid sheath. Plasma cells accumulate in the red pulp. The white pulp has two components: the eccentric follicles (Malpighian corpuscles) seen in Figure 1, and the periarteriolar lymphoid sheath seen here. The follicles are identical to lymph node follicles (B cell zones), while the periarteriolar sheath is identical to lymph node paracortex (T cell zone).

View larger version (143K): [in this window] [in a new window]   Figure 3. The spleen has follicles with prominent marginal zones, with memory B cells occupying the marginal zones.

View larger version (144K): [in this window] [in a new window]   Figure 4. The spleen has follicles with prominent marginal zones, with memory B cells occupying the marginal zones.

View larger version (157K): [in this window] [in a new window]   Figure 5. The T cell zones are architecturally similar to those of lymph nodes, with numerous interdigitating dendritic cells (IDC).

View larger version (138K): [in this window] [in a new window]   Figure 6. The red pulp is a site of filtration of particles from the blood, including microbes and red blood cell nuclei. The PAS stain is useful for visualizing the fenestrated basement membrane of the sinuses, which, together with the littoral cells lining the sinuses, form a meshwork through which particles must pass to re-enter the circulation.

View larger version (139K): [in this window] [in a new window]   Figure 7. Peyer's patch of ileum, showing prominent reactive germinal centers, with broad marginal zones. Specialized lymphoid tissue is found in association with certain epithelia, in particular the naso- and oro-pharynx (Waldeyer's ring: adenoids, tonsils), the gastrointestinal tract (gut-associated lymphoid tissue: Peyer's patches of the distal ileum, mucosal lymphoid aggregates in the colon and rectum), and lung (bronchus-associated lymphoid tissue). Collectively, this is known as mucosa-associated lymphoid tissue (MALT). These tissues tend to have prominent B cell follicles, but also may have discrete T cell zones, similar to the paracortex of lymph nodes. MALT is thought to function in response to intraluminal antigens and the generation of mucosal immunity. Lymphoid cells that respond to antigen in the MALT acquire homing properties that enable them to return to these tissues.

View larger version (147K): [in this window] [in a new window]   Figure 8. Peyer's patch, showing germinal center, mantle zone, and marginal zone of larger cells with irregular nuclei and a moderate amount of pale cytoplasm. Specialized lymphoid tissue is found in association with certain epithelia, in particular the naso- and oro-pharynx (Waldeyer's ring: adenoids, tonsils), the gastrointestinal tract (gut-associated lymphoid tissue: Peyer's patches of the distal ileum, mucosal lymphoid aggregates in the colon and rectum), and lung (bronchus-associated lymphoid tissue). Collectively, this is known as mucosa-associated lymphoid tissue (MALT). These tissues tend to have prominent B cell follicles, but also may have discrete T cell zones, similar to the paracortex of lymph nodes. MALT is thought to function in response to intraluminal antigens and the generation of mucosal immunity. Lymphoid cells that respond to antigen in the MALT acquire homing properties that enable them to return to these tissues.

View larger version (157K): [in this window] [in a new window]   Figure 9. Adenoid, showing pale staining marginal zone exending toward epithelium of crypt. Specialized lymphoid tissue is found in association with certain epithelia, in particular the naso- and oro-pharynx (Waldeyer's ring: adenoids, tonsils), the gastrointestinal tract (gut-associated lymphoid tissue: Peyer's patches of the distal ileum, mucosal lymphoid aggregates in the colon and rectum), and lung (bronchus-associated lymphoid tissue). Collectively, this is known as mucosa-associated lymphoid tissue (MALT). These tissues tend to have prominent B cell follicles, but also may have discrete T cell zones, similar to the paracortex of lymph nodes. MALT is thought to function in response to intraluminal antigens and the generation of mucosal immunity. Lymphoid cells that respond to antigen in the MALT acquire homing properties that enable them to return to these tissues.

View larger version (137K): [in this window] [in a new window]   Figure 10. Adenoid, showing infiltration of epithelium by marginal zone B lymphocytes. Specialized lymphoid tissue is found in association with certain epithelia, in particular the naso- and oro-pharynx (Waldeyer's ring: adenoids, tonsils), the gastrointestinal tract (gut-associated lymphoid tissue: Peyer's patches of the distal ileum, mucosal lymphoid aggregates in the colon and rectum), and lung (bronchus-associated lymphoid tissue). Collectively, this is known as mucosa-associated lymphoid tissue (MALT). These tissues tend to have prominent B cell follicles, but also may have discrete T cell zones, similar to the paracortex of lymph nodes. MALT is thought to function in response to intraluminal antigens and the generation of mucosal immunity. Lymphoid cells that respond to antigen in the MALT acquire homing properties that enable them to return to these tissues.

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This Article Figures Only Services Similar articles in this journal Alert me to new content in the Image Bank Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Harris, N. L. Search for Related Content PubMed Articles by Harris, N. L. Related Collections Reactive Conditions of Lymph Nodes and Spleen Related ASH-SAP Chapter Related Image Bank Image Sets Social Bookmarking                   What's this?