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Mantle Cell Lymphoma

Beth Israel Deaconess Medical Center

View larger version (152K): [in this window] [in a new window]   Figure 1. Mantle cell lymphoma, lymph node - Broad mantle zones surround two residual germinal centers. Preserved lymph node architecture is seen at left of image (4x objective lens).

View larger version (169K): [in this window] [in a new window]   Figure 2. Mantle cell lymphoma, lymph node - Remnants of germinal center with starry sky macrophages surrounded by expanded mantle zone (10x objective lens).

View larger version (166K): [in this window] [in a new window]   Figure 3. Mantle cell lymphoma, lymph node - Atrophied germinal center surrounded by expanded mantle zone (10x objective lens).

View larger version (162K): [in this window] [in a new window]   Figure 4. Mantle cell lymphoma - Germinal center overrun by broadened mantle zone (20x objective lens), lymph node.

View larger version (151K): [in this window] [in a new window]   Figure 5. Mantle cell lymphoma, lymph node - Monotonous population of small to medium-sized neoplastic lymphocytes with few scattered hyalinized blood vessels characteristic of mantle cell lymphoma.

View larger version (129K): [in this window] [in a new window]   Figure 6. Mantle cell lymphoma, Monotonous population of small to medium-sized lymphocytes with dispersed chromatin and inconspicuous nucleoli. Some nuclei appear indented or folded resembling centrocytes of normal germinal centers (objective lens x100).

View larger version (148K): [in this window] [in a new window]   Figure 7. Mantle cell lymphoma, bcl-1 stain of lymphoma cells, sparing non-neoplastic germinal center.

View larger version (155K): [in this window] [in a new window]   Figure 8. Mantle cell lymphoma, spleen - nodular pattern with expanded mantle zones.

View larger version (157K): [in this window] [in a new window]   Figure 9. Mantle cell lymphoma, spleen - tumor nodule with expanded mantle zone.

View larger version (139K): [in this window] [in a new window]   Figure 10. Mantle cell lymphoma - Blastic variant with pleomorphic nuclei, prominent nucleoli and mitotic activity.

View larger version (134K): [in this window] [in a new window]   Figure 11. Mantle cell lymphoma, colon - low power view of neoplastic cells surrounding germinal centers, small area of normal intestinal epithelium.

View larger version (140K): [in this window] [in a new window]   Figure 12. Mantle cell lymphoma, lymphoma replacing colonic mucosa in intestinal lymphomatous polyposis.

View larger version (121K): [in this window] [in a new window]   Figure 13. Mantle cell lympoma, gross pathology - Colonic mucosa studded by tumor nodules in intestinal lymphomatous polyposis.

View larger version (167K): [in this window] [in a new window]   Figure 14. Mantle cell lymphoma, lymph node - Blastoid variant with pale tumor cells surrounding germinal center.

View larger version (149K): [in this window] [in a new window]   Figure 15. Mantle cell lymphoma, lymph node - separated tumor nodules with intact lymph node sinuses.

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