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Refractory Anemia with Ringed Sideroblasts (RARS)

View larger version (123K): [in this window] [in a new window]   Figure 1. Red blood cells are macrocytic (MCV 104)and exhibit mild aniso- and poikilocytosis. Only a rare polychromatophilic cell is seen. A Pelger-Huet-like neutrophil is present.

View larger version (132K): [in this window] [in a new window]   Figure 2. The Pelger-Huet morphology of the neutrophil is more apparent at higher magnification (100x).

View larger version (125K): [in this window] [in a new window]   Figure 3. Cellular marrow with erythroid hyperplasia. The blast population is not increased. Minimal dysplastic changes are present inthe erythroid series.(10x)

View larger version (111K): [in this window] [in a new window]   Figure 4. Marked erythroid hyperplasia is more evident at higher magnisfication. Binucleated erythroid precursors are present. Cytoplasm on many of the erythroid precursors has shaggy borders. Howell-Jolly bodies are also present. (20x)

View larger version (104K): [in this window] [in a new window]   Figure 5. The marrow shows 60% cellularity due primarily to erythroid hyperplasia. Megakaryocytes show dysplastic changes. Clusters of immature myeloid precursors are also evident.

View larger version (118K): [in this window] [in a new window]   Figure 6. Higher magnification of previous image shows the marked erythroid hyperplasia with marked increase in early to intermediate forms. Megakaryocytic dysplasia and clustering of immature myeloid precursors are evident.

View larger version (143K): [in this window] [in a new window]   Figure 7. Low magnification view of the marrow aspirate shows marked increase in marrow iron.

View larger version (127K): [in this window] [in a new window]   Figure 8. Late erythroid forms showing ringed siderobalsts are depicted.

View larger version (146K): [in this window] [in a new window]   Figure 9. Both ringed sideroblasts and an iron-laden macrophage are show in this view.

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This Article Figures Only Services Similar articles in this journal Alert me to new content in the Image Bank Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Lazarchick, J. Search for Related Content PubMed Articles by Lazarchick, J. Related Collections Myelodysplastic Syndromes Related ASH-SAP Chapter Related Image Bank Image Sets Related ASH Education Book Articles Social Bookmarking                   What's this?