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Metastatic Prostatic Carcinoma

View larger version (153K): [in this window] [in a new window]   Figure 1. 64 year old male presented with back pain. His peripheral smear showed leukoerythroblastic features including tear drop RBCs, nucleated RBCs and immature myeloid precursors. Multiple attempts at marrow aspiration were unsuccessful. The marrow biopsy shows the marrow to be completely replaced by tumor cells interspersed in a dense fibrotic (desmoplastic) stroma. Ill-defined glandular structures were present(arrow). (H&E 4x)

View larger version (145K): [in this window] [in a new window]   Figure 2. A large glandular structure is evident in this view. These cells were positive on immunohistochemical staining with anti-cytokeratin and prostate-specific antigen (PSA)antisera, consistent with metastatic prostatic carcinoma. (H&E 10x)

View larger version (174K): [in this window] [in a new window]   Figure 3. In another area of the the biopsy, two large glandular structures were seen in addition to single poorly-differentiated tumor cells in the fibrous stromal background. (H&E 10x)

View larger version (145K): [in this window] [in a new window]   Figure 4. The tumor cells forming the glandular structure have abundant cytoplasm and hyperchromatic nuclei. Cellular debris is present within the duct. Elongated fibroblast nuclei are readily identified surrounding the structure. (H&E 40x)

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This Article Figures Only Services Similar articles in this journal Alert me to new content in the Image Bank Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Lazarchick, J. Search for Related Content PubMed Articles by Lazarchick, J. Related Collections Miscellaneous lesions Related ASH-SAP Chapter Related Image Bank Image Sets Social Bookmarking                   What's this?