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Bone Marrow Necrosis

View larger version (137K): [in this window] [in a new window]   Figure 1. Bone marrow aspirate from a 57 year old male on long-term methotrexate therapy for rheumatoid arthritis is shown. Note intense blue staining of residual necrotic tissue. Individual marrow elements can not be identified.

View larger version (107K): [in this window] [in a new window]   Figure 2. At a higher magnification the outline of necrotic cells can be seen within the amorphous material but individual cells can not be identified. (Wright-Giemsa 50x)

View larger version (175K): [in this window] [in a new window]   Figure 3. Although the marrow structure is intact, viable cells are not present and there is homogeneous staining of all cellular elements consistent with marrow necrosis. (H&E 10x)

View larger version (137K): [in this window] [in a new window]   Figure 4. At a higher magnification, nuclear outlines of individual cells are evident within a milieu of necrotic debris. (H&E 40x)

View larger version (173K): [in this window] [in a new window]   Figure 5. Marked scalloping of the bony trabecula can be seen in this view. Note the homogeneous staining of the necrotic marrow. (H&E 10x)

View larger version (166K): [in this window] [in a new window]   Figure 6. A partially thrombosed blood vessel can be seen (arrow) in this view. An area of normal residual marrow elements is also evident in addition to the the area of necrosis.

View larger version (172K): [in this window] [in a new window]   Figure 7. A thrombosed blood vessel is evident in this view from another section of the marrow biopsy. (H&E 10x)

View larger version (161K): [in this window] [in a new window]   Figure 8. At higher magnification, organization of the thrombus can be seen. There is evidence of initial lysis of the thrombus with recannulization. (H&E 40x)

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This Article Figures Only Services Similar articles in this journal Alert me to new content in the Image Bank Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Lazarchick, J. Search for Related Content PubMed Articles by Lazarchick, J. Related Collections Response and regeneration of marrow following therapy and/or toxic insults Related ASH-SAP Chapter Related Image Bank Image Sets Social Bookmarking                   What's this?