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AML with t(8; 21)

View larger version (114K): [in this window] [in a new window]   Figure 1. Blast circulating in the peripheral blood.

View larger version (99K): [in this window] [in a new window]   Figure 2. Auer rods (arrow) are common in this disorder and tend to occur as single thin structures within the cytoplasm of the blasts.

View larger version (94K): [in this window] [in a new window]   Figure 3. Cytoplasm of some of the blasts may be intensely basophilic. Nuclei may be indented.

View larger version (89K): [in this window] [in a new window]   Figure 4. Arrow marks "thumbprinting" which is characteristic of myeloid blasts.

View larger version (78K): [in this window] [in a new window]   Figure 5. Few faint granules may be present in the cytoplasm of the blasts.

View larger version (165K): [in this window] [in a new window]   Figure 6. Blasts are increased in the bone marrow and,although many of the cells appear to have a centrosome, maturation is arrested.

View larger version (123K): [in this window] [in a new window]   Figure 7. Some blasts have prominent nucleoli.

View larger version (121K): [in this window] [in a new window]   Figure 8. Centrosomes are evidence of myeloid differentiation.

View larger version (120K): [in this window] [in a new window]   Figure 9. Some of the nuclei are folded and somewhat irregular.

View larger version (78K): [in this window] [in a new window]   Figure 10. Diagram of the t(8;21)(q22;q22) rearrangement which characterizes this disorder and results in the molecular fusion of part of the AML1 gene at 8q22 with part of the ETO gene from 21q22.

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This Article Figures Only Services Similar articles in this journal Alert me to new content in the Image Bank Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Maslak, P. Search for Related Content PubMed Articles by Maslak, P. Related Collections Acute Myeloid Leukemia Related ASH-SAP Chapter Social Bookmarking                   What's this?