Figure 1. Peripheral smear from a 45 year old male with alcoholic cirrhosis. His WBC was 3110 with 80% of his neutrophils showing hyposegmentation. A bi-lobed (pince-nez) form is shown in this view.
Figure 3. The Pelger-Huet forms in this view show toxic granulation and cytoplasmic vacuolization. In addition, numerous target cells are present as well as polychromatophilic RBCs. The patient had been seen because of GI bleeding.
Figure 4. A higher power view of the previous image better illustrates the mature nucleus of the Pelger-Huet cell. The chromatin is clumped and the nucleus slightly indented. There is a suggestion of a Dohle body abutting the cytoplasmic membrane.
Figure 6. A low power view of the peripheral smear illustrates the variant Pelger-Huet forms present, from the classical pince-nez shape to that of round or slightly indented nuclear forms. Similar findings were documented on this patient's peripheral smear 10 years previously.
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