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Pelger-Huet Anomoly

View larger version (89K): [in this window] [in a new window]   Figure 1. Peripheral smear from a 45 year old male with alcoholic cirrhosis. His WBC was 3110 with 80% of his neutrophils showing hyposegmentation. A bi-lobed (pince-nez) form is shown in this view.

View larger version (100K): [in this window] [in a new window]   Figure 2. The neutrophils in this view show mature nuclei with coarse clumped chromatin but no segmentation or are only minimally indented.

View larger version (94K): [in this window] [in a new window]   Figure 3. The Pelger-Huet forms in this view show toxic granulation and cytoplasmic vacuolization. In addition, numerous target cells are present as well as polychromatophilic RBCs. The patient had been seen because of GI bleeding.

View larger version (68K): [in this window] [in a new window]   Figure 4. A higher power view of the previous image better illustrates the mature nucleus of the Pelger-Huet cell. The chromatin is clumped and the nucleus slightly indented. There is a suggestion of a Dohle body abutting the cytoplasmic membrane.

View larger version (82K): [in this window] [in a new window]   Figure 5. The bi-lobed neutrophil in this image shows more clearly the toxic granulation, cytoplasmic vacuolization and bluish Dohle body.

View larger version (145K): [in this window] [in a new window]   Figure 6. A low power view of the peripheral smear illustrates the variant Pelger-Huet forms present, from the classical pince-nez shape to that of round or slightly indented nuclear forms. Similar findings were documented on this patient's peripheral smear 10 years previously.

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This Article Figures Only Services Similar articles in this journal Alert me to new content in the Image Bank Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Lazarchick, J. Search for Related Content PubMed Articles by Lazarchick, J. Related Collections Phagocytic disorders - Chediak-Higashi, Pelger-Huet, May-Hegglin Related ASH-SAP Chapter Related Image Bank Image Sets Related ASH Education Book Articles Social Bookmarking                   What's this?