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ASH Image Bank (2004); doi:10.1182/ashimagebank-2004-101168
Copyright © 2004 by the American Society of Hematology.
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Atlas Image Set

Pappenheimer Bodies

John Lazarchick



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Figure 1. Peripheral smear from a patient with alcoholic liver disease. The hypochromic RBC to the right of center contains three small blue granular, irregular-shaped inclusions on the periphery of the RBC. These iron-containing (ferritin) granules are called Pappenheimer bodies and can be seen on a Wright-Giemsa stained blood smear. A Prussian Blue stain is need to confirm the presence of non-heme iron in the granules.

 


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Figure 2. Multiple RBCs containing Pappenheimer bodies are seen in htis view. The granules are of variable size and are present predominantly in the polychromatophilic RBCs

 


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Figure 3. The RBC in the lower left of the image contains numerous inclusions of variable size. Finer, smaller granules are noted in the RBC on the right.

 


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Figure 4. A higher power view of the previous image shows the granules more distinctly. They essentially circumscribe the periphery of the polychromatophilic RBC.

 

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Related ASH-SAP Chapter:space logo
Chapter 4: Iron metabolism, iron overload and the porphyrias

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Right arrow Articles by Lazarchick, J.
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Copyright © 2004 by the American Society of Hematology.