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Granular ALL

Memorial Sloan-Kettering Cancer Center

Peter Maslak

View larger version (113K): [in this window] [in a new window]   Figure 1. Peripheral blood reveals circulating blasts with scant cytoplasm.

View larger version (94K): [in this window] [in a new window]   Figure 2. High power view reveals that some of the blasts have distinctive azurophilic granules. Flow cytometry demonstrates pre-B immunophenotype.

View larger version (53K): [in this window] [in a new window]   Figure 3. The blast population (red) is defined by CD45 and side scatter gating.

View larger version (46K): [in this window] [in a new window]   Figure 4. Blasts are Tdt positive.

View larger version (49K): [in this window] [in a new window]   Figure 5. Blasts dual-express CD19 and CD10.

View larger version (44K): [in this window] [in a new window]   Figure 6. Blasts express CD19 (B lineage) but not CD13 (myeloid lineage).

View larger version (42K): [in this window] [in a new window]   Figure 7. Blasts express CD22 (B lineage) but not CD2 (T lineage).

View larger version (76K): [in this window] [in a new window]   Figure 8. Blasts co-express CD10 and HLA-DR.

View larger version (53K): [in this window] [in a new window]   Figure 9. Blasts express CD34 (stem cell) but not CD33 (myeloid lineage).

View larger version (87K): [in this window] [in a new window]   Figure 10. Many of the blasts have morphology more typical of ALL; a high nuclear-cytoplasmic ratio devoid of granules.

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This Article Figures Only Services Similar articles in this journal Alert me to new content in the Image Bank Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Rose, R. Articles by Maslak, P. Search for Related Content PubMed Articles by Rose, R. Articles by Maslak, P. Related Collections Precursor B-cell Acute Lymphoblastic Leukemia Related ASH-SAP Chapter Social Bookmarking                   What's this?