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ASH Image Bank (2004); doi:10.1182/ashimagebank-2004-101172
Copyright © 2004 by the American Society of Hematology.
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Atlas Image Set

Granular ALL

Ruth Rose

Memorial Sloan-Kettering Cancer Center

Peter Maslak



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Figure 1. Peripheral blood reveals circulating blasts with scant cytoplasm.

 


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Figure 2. High power view reveals that some of the blasts have distinctive azurophilic granules. Flow cytometry demonstrates pre-B immunophenotype.

 


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Figure 3. The blast population (red) is defined by CD45 and side scatter gating.

 


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Figure 4. Blasts are Tdt positive.

 


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Figure 5. Blasts dual-express CD19 and CD10.

 


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Figure 6. Blasts express CD19 (B lineage) but not CD13 (myeloid lineage).

 


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Figure 7. Blasts express CD22 (B lineage) but not CD2 (T lineage).

 


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Figure 8. Blasts co-express CD10 and HLA-DR.

 


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Figure 9. Blasts express CD34 (stem cell) but not CD33 (myeloid lineage).

 


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Figure 10. Many of the blasts have morphology more typical of ALL; a high nuclear-cytoplasmic ratio devoid of granules.

 

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Related ASH-SAP Chapter:space logo
Chapter 11: Acute lymphoblastic leukemia and lymphoblastic lymphoma

This Article
Right arrow Figures Only
Services
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Right arrow Alert me to new content in the Image Bank
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Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rose, R.
Right arrow Articles by Maslak, P.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Rose, R.
Right arrow Articles by Maslak, P.
Related Collections
Right arrow Precursor B-cell Acute Lymphoblastic Leukemia
Right arrow Related ASH-SAP Chapter
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Copyright © 2004 by the American Society of Hematology.