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Marrow Germinal Center

View larger version (175K): [in this window] [in a new window]   Figure 1. A discrete germinal center is present (left-center of image) in this otherwise normal marrow biopsy. The patient is a 63-year-old male who was being evaluated for anemia. (H&E 10x)

View larger version (173K): [in this window] [in a new window]   Figure 2. At a higher magnification, the darker-staining small mantle cell lymphocytes surround the paler-staining follicular center cells.

View larger version (182K): [in this window] [in a new window]   Figure 3. The follicular center cells are larger than the surrounding mantle cells. There are intermediate-sized cells with cleaved nuclear borders (centrocytes), larger blast-like cells (centroblasts) and pale staining macrophages with abundant cytoplasm containing debris.

View larger version (175K): [in this window] [in a new window]   Figure 4. The cellular composition of the mantle and follicular center regions are more readily seen in this higher power image.

View larger version (154K): [in this window] [in a new window]   Figure 5. Immunohistochemical staining with anti-CD 20 highlights the B-cell lymphocytes of the germinal center (mantle zone and follicular center). In addition scattered B-cells can be seen throughout the remainder of the specimen.

View larger version (182K): [in this window] [in a new window]   Figure 6. The CD 20 staining cells of the mantle zone and follicular center are better defined in this higher magnification of the previous image.

View larger version (163K): [in this window] [in a new window]   Figure 7. Immunohistochemical staining with anti-CD5 highlights the B cells of the mantle zone (dark staining cells). Note that the follicular center B-cells are CD5 negative.

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This Article Figures Only Services Similar articles in this journal Alert me to new content in the Image Bank Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Lazarchick, J. Search for Related Content PubMed Articles by Lazarchick, J. Related Collections Lymphoid hyperplasia Related ASH-SAP Chapter Related Image Bank Image Sets Social Bookmarking                   What's this?