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Accelerated Phase of CML

View larger version (91K): [in this window] [in a new window]   Figure 1. Peripheral blood shows a marked leukocytosis.

View larger version (80K): [in this window] [in a new window]   Figure 2. The white blood cell count is high and some of the cells appear to cluster together in the peripheral blood.

View larger version (94K): [in this window] [in a new window]   Figure 3. Under high power, immature myeloid forms including blasts are noted. Basophils are also seen.

View larger version (94K): [in this window] [in a new window]   Figure 4. Some of the granulocytes are dysplastic with abnormal lobulation of the nuclei.

View larger version (87K): [in this window] [in a new window]   Figure 5. This high power view provides an illustration of some of the dysplastic myeloid features. The large basophilic cell on the right appear to have a small Auer rod in the cytoplasm. Auer rods are generally not found in accelerated/blast phases of CML, however.

View larger version (188K): [in this window] [in a new window]   Figure 6. The bone marrow aspirate is markedly hypercellular.

View larger version (129K): [in this window] [in a new window]   Figure 7. Blasts are increased but account for less than 20% of the nucleated cells in the bone marrow. An eosinophilic precursor is also seen in the middle of the field.

View larger version (154K): [in this window] [in a new window]   Figure 8. Dysplastic changes may occur with transformation to the more aggressive phases of disease.

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This Article Figures Only Services Similar articles in this journal Alert me to new content in the Image Bank Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Maslak, P. Search for Related Content PubMed Articles by Maslak, P. Related Collections Myeloproliferative Diseases Related ASH-SAP Chapter Social Bookmarking                   What's this?