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Sézary Syndrome

View larger version (113K): [in this window] [in a new window]   Figure 1. Generalized erythoderma in a patient with Sézary syndrome-a triad of erythroderma, lymphadenopathy and circulating neoplastic lymphocytes. Patients often experience intense itching and loss of body heat through skin.

View larger version (111K): [in this window] [in a new window]   Figure 2. Blood smear stained with Giemsa showing Sézary cell with convoluted nucleus. Sézary cells may be confused with monocytes which are of similar size and have a folded nucleus. Further distinction is facilitated by Periodic-acid-Schiff (PAS) stain which shows coarse granules surrounding the nucleus in cytoplasm of Sézary cells and fine dispersed granules in monocytes. Flow cytometry will also identify Sézary cells as T cells which express surface CD3 and CD4, but commonly lack CD7 antigen.

View larger version (137K): [in this window] [in a new window]   Figure 3. Higher magnification of Sézary cell with convoluted nulceus and small nucleoli.

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This Article Figures Only Services Similar articles in this journal Alert me to new content in the Image Bank Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Kadin, M. Search for Related Content PubMed Articles by Kadin, M. Related Collections T-Cell and NK-Cell Neoplasms Related ASH-SAP Chapter Related Image Bank Image Sets Related ASH Education Book Article Social Bookmarking                   What's this?