HOME HELP FEEDBACK SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Services Similar articles in this journal Alert me to new content in the Image Bank Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Lazarchick, J. Search for Related Content PubMed Articles by Lazarchick, J. Related Collections Acute Myeloid Leukemia Related ASH-SAP Chapter Related Image Bank Image Sets Related ASH Education Book Articles Social Bookmarking                   What's this?

Chemotherapy-Related AML, M4e

View larger version (130K): [in this window] [in a new window]   Figure 1. The monocytoid-appearance of the blasts I more evident in this view of the peripheral smear. The two central cells are atypical monocytes; the blast cell on the right can not be assigned a lineage based on morphology; the remaining two cells are promonocytes.

View larger version (113K): [in this window] [in a new window]   Figure 2. Two blasts are seen in this view. The one on the left contains a single Auer rod. Granules, however, are not present in the cytoplasm of either blast.

View larger version (158K): [in this window] [in a new window]   Figure 3. The marrow aspirate is markedly cellular. Even at this magnification, one can appreciate an increased blast population and an apparent hyperplasia of eosinophils and eosinophilic precursors. Few erythroid precursors are noted.

View larger version (136K): [in this window] [in a new window]   Figure 4. At higher magnification, the marked increase in blasts , some with round nuclei and others with irregular, convoluted nuclei, can be seen. Dysplastic eosinophilic precursors are prominent.

View larger version (141K): [in this window] [in a new window]   Figure 5. The dysplastic eosinophilic precursors are better seen in this view. Some of these cells contain both eosinophilc and basophilic granules. Other large blast-like cells multiple eosinophilic inclusions.

View larger version (82K): [in this window] [in a new window]   Figure 6. Both myeloid and monocytoid blasts are seen in this image in addition to the aberrant eosinophilic precursors. The cytogenetic and FISH analyses revealed an inv chromosome 16 consistent with AML – M4e and a trisomy 22.

View larger version (167K): [in this window] [in a new window]   Figure 7. Dual esterase stain is positive for both myeloid (magenta) and monoblasts (black), approximately equal in number.

View larger version (135K): [in this window] [in a new window]   Figure 8. At higher magnification of the previous image, variable intensity of staining of individual myeloid and monocytoid blasts with dual esterase can be appreciated.

View larger version (143K): [in this window] [in a new window]   Figure 9. The marrow cellularity is essentially 100%.

View larger version (174K): [in this window] [in a new window]   Figure 10. The extensive eosinophilic proliferation is more apparent in this view. Rare erythroid precursors are present. The variable nuclear contours of the blasts are evident.

View larger version (151K): [in this window] [in a new window]   Figure 11. A higher magnification of the previous image is shown. Note the marked variability in blast morphology and the extensive proliferation of eosinophils and eosinophilic precursors.

CiteULike

Connotea

Del.icio.us

Digg

Reddit

Technorati

Related Image Bank Image Sets

Acute Myeloid Leukemia with inv 16

Peter Maslak and Susan McKenzie
ASH Image Bank 2002 2002: 100528. [Full Text]

AML with inv(16)

John Lazarchick
ASH Image Bank 2004 2004: 101005. [Full Text]

AML - M4e

John Lazarchick
ASH Image Bank 2004 2004: 101148. [Full Text]

AMML Eo

Peter Maslak
ASH Image Bank 2004 2004: 101218. [Full Text]

AMML Eo

Peter Maslak
ASH Image Bank 2005 2005: 101374. [Full Text]

Related ASH Education Book Articles

Chromosome Aberrations, Gene Mutations and Expression Changes, and Prognosis in Adult Acute Myeloid Leukemia

Krzysztof Mrózek and Clara D. Bloomfield
Hematology 2006 2006: 169-177. [Abstract] [Full Text]

FLT3 Mutations: Biology and Treatment

Donald Small
Hematology 2006 2006: 178-184. [Abstract] [Full Text]

Controversies in Treatment of AML: Case-based Discussion

Wendy Stock
Hematology 2006 2006: 185-191. [Abstract] [Full Text]

Related ASH-SAP Chapter:

This Article Figures Only Services Similar articles in this journal Alert me to new content in the Image Bank Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Lazarchick, J. Search for Related Content PubMed Articles by Lazarchick, J. Related Collections Acute Myeloid Leukemia Related ASH-SAP Chapter Related Image Bank Image Sets Related ASH Education Book Articles Social Bookmarking                   What's this?