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Mycosis Fungoides

View larger version (125K): [in this window] [in a new window]   Figure 1. Skin biopsy showing band-like infiltrate of atypical lymphocytes in upper (papillary) dermis.

View larger version (130K): [in this window] [in a new window]   Figure 2. Epidermotropism of atypical lymphocytes with cerebriform nuclei. Lymphocytes appear in the basal layer of the epidermis and at the dermal-epidermal junction. Some lymphocytes have a clear space (halo) around them which is a diagnostic feature of mycosis fungoides.

View larger version (131K): [in this window] [in a new window]   Figure 3. Collection of atypical lymphocytes with convoluted (ceribriform) nuclei in epidermis. Collections of 3 or more atypical lymphocytes in the epidermis are known as a Pautrier microabscess and are a diagnostic feature of mycosis fungoides and it's leukemic variant, the Sezary syndrome.

View larger version (140K): [in this window] [in a new window]   Figure 4. Epidermotropism of atypical lymphocytes with cerebriform nuclei. Lymphocytes appear in the basal layer of the epidermis and at the dermal-epidermal junction. Some lymphocytes have a clear space (halo) around them which is a diagnostic feature of mycosis fungoides. In one area near the top of the image the lymphocytes are in contact with a collection of Langerhans cells which are antigen presenting cells in the epidermis and are thought to be involved in the pathogenesis of mycosis fungoides. They are distinguished from mycosis fungoides lymphocytes by their pale staining nuclei and abundant cytoplasm.

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This Article Figures Only Services Similar articles in this journal Alert me to new content in the Image Bank Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Kadin, M. Search for Related Content PubMed Articles by Kadin, M. Related Collections T-Cell and NK-Cell Neoplasms Related ASH-SAP Chapter Related Image Bank Image Sets Related ASH Education Book Articles Social Bookmarking                   What's this?