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Anaplastic Large Cell Lymphoma

Children's Hospital Orange County CA

Marshall Kadin

L. Jeffrey Medeiros, M.D.

Anderson Cancer Hospital, Houston TX

Attilio Orazi, M.D.

Richard Neiman, M.D.

Indiana University School of Medicine

View larger version (177K): [in this window] [in a new window]   Figure 1. Chest wall biopsy reveals monomorphic appearance of large cells and frequent mitoses indicating a rapidly growing tumor. The lymphoma cells express T-cell antigen CD45RO, ALK oncoprotein and CD30, and are negative for B cell antigen CD20, kappa and lambda light chains. Without immunohistochemical studies, this monomorphic appearance would be difficult to distinguish from a large cell lymphoma of B-cell origin. Importantly, the ALK+ lymphomas have a generally better prognosis than large B-cell lymphomas of similar stage.

View larger version (170K): [in this window] [in a new window]   Figure 2. This testicular lymphoma has many anaplastic cells including multinucleated cells typical of anaplastic large cell lymphoma. There are also many apoptotic bodies indicating cell death. Extranodal sites of presentation, e.g. the testis, are common (40%) in patients with anaplastic large cell lymphoma. The tumor cells in this example express CD30 and T-cell antigen CD3, and are negative for B-cell antigen CD20. The differential diagnosis would include anaplastic germ cell tumor of the testis but immunohistochemistry is supports the diagnosis of anaplastic large cell lymphoma.

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This Article Figures Only Services Similar articles in this journal Alert me to new content in the Image Bank Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Lones, M. Articles by Neiman, R. Search for Related Content PubMed Articles by Lones, M. Articles by Neiman, R. Related Collections T-Cell and NK-Cell Neoplasms Related ASH-SAP Chapter Related Image Bank Image Sets Related ASH Education Book Article Social Bookmarking                   What's this?