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Metastatic Prostatic Carcinoma

View larger version (164K): [in this window] [in a new window]   Figure 1. The patient is a 70 year old male who was diagnosed with AML-M1 and underwent two standard induction therapies. He was then placed on Mylotarg as therapy for residual disease. His CBC at this time showed a hemoglobin of 10g/dL, WBC of 5k/uL with a normal differential and a platelet count of 446k/uL. A peripheral smear shows moderate anisocytosis and poikilocytosis. Microspherocytes, polychromatophilic and fragmented RBCs are present. Tear-drop RBCs can also be seen.

View larger version (154K): [in this window] [in a new window]   Figure 2. A low-powered view of the marrow aspirate is shown. Large groups of homogenous-appearing cells are noted. These cells have a high nuclear/cytoplasmic ratio. Normal hematopoietic elements are not identifiable.

View larger version (157K): [in this window] [in a new window]   Figure 3. At a higher magnification of one of these groups, the cells have a slightly basophilic cytoplasm, nuclei with a fine chromatin pattern and contain one or more large nucleoli. Cytoplasmic vacuolization is present in some of the cells.

View larger version (96K): [in this window] [in a new window]   Figure 4. In this group molding of the cells is more apparent. Prominent nucleoli are also evident. There is a suggestion of gland formation in the lower area of the cellular group.

View larger version (153K): [in this window] [in a new window]   Figure 5. The bone marrow biopsy is cellular and appears to have two distinct regions. There is a hypocellular area on the upper right; cellular elements interspersed among the fat cells are evident in the remainder of the biopsy.

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This Article Figures Only Services Similar articles in this journal Alert me to new content in the Image Bank Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Lazarchick, J. Search for Related Content PubMed Articles by Lazarchick, J. Related Collections Miscellaneous lesions Related ASH-SAP Chapter Related Image Bank Image Sets Related ASH Education Book Article Social Bookmarking                   What's this?