ASH Image Bank
HOME HELP FEEDBACK SEARCH
QUICK SEARCH:   [advanced]


     

ASH Image Bank (2005); doi:10.1182/ashimagebank-2005-101346
Copyright © 2005 by the American Society of Hematology.
This Article
Right arrow Figures Only
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new content in the Image Bank
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lazarchick, J.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Lazarchick, J.
Related Collections
Right arrow B-Cell Neoplasms
Right arrow Related ASH-SAP Chapter
Right arrowRelated Image Bank Image Sets
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Atlas Image Set

Plasmacytoma

John Lazarchick



View larger version (143K):
[in this window]
[in a new window]
  		Figure 1. 58 year old male presented with complaint of back pain. An x-ray of the thoracic spine showed a lytic lesion at T4. An open biopsy was performed and a low power view of the lesion in shown. Cell nuclei can be seen scattered throughout the lesion separated by light-staining amorphous matrix.

 


View larger version (173K):
[in this window]
[in a new window]
  		Figure 2. At a slightly higher power view, fibrous bands can be seen in some areas of the biopsy. Although abundant nuclei are readily but distinct cytoplasmic borders are not apparent. Crush artifact is also noted.

 


View larger version (179K):
[in this window]
[in a new window]
  		Figure 3. In this view, cells with large azurophilic nucleoli are noted, particularly in the top half of the filed. These cells are large and are not adherent to each other. Many appear to have pink-staining cytoplasm and do contain cytoplasmic granules.

 


View larger version (180K):
[in this window]
[in a new window]
  		Figure 4. The cells are most distinct in this high power view. Several morphologic variants are evident, including cells with a vesicualted nucleus and large acidophilic central nucleous, group with smaller nucleus but also containing large nucleolus similar to the large cells, a second group of smaller cells with dot-like parachromatin distributed in a clock-like fashion in the nucleus and finally a number of apoptotic cells.

 


View larger version (182K):
[in this window]
[in a new window]
  		Figure 5. This view is from another site on the specimen and shows a similar cellular infiltrate. The plasmacytoid appearance of the nuclei of many of the cells is more apparent in this view.

 


View larger version (174K):
[in this window]
[in a new window]
  		Figure 6. A higher magnification of the previous image is shown. There appears to be two patterns of nuclei in these cells, those with a vseiculated nucleus and those with a chromatin pattern seen in plasma cells. Large nucleoli are present in both types.

 


View larger version (172K):
[in this window]
[in a new window]
  		Figure 7. A high power view of the cells with vesiculated nuclei is shown. Note that distinct cytoplasmic borders are not apparent and that the cytoplasm in all cells is vacuolated.

 


View larger version (181K):
[in this window]
[in a new window]
  		Figure 8. Immunohistochemicalstaining with anti-CD 138 antibody is shown. Diffuse staining is present consistent with the lesion being a plasmcytoma.

 


View larger version (170K):
[in this window]
[in a new window]
  		Figure 9. The CD 138 positivity is shown at a higher magnification. The stain outlines the cytoplasm of the plasma cells.

 


View larger version (159K):
[in this window]
[in a new window]
  		Figure 10. In this view of the CD 138 stain, the large nucleoli is easily seen in some of the plasma cells/plasmablasts.

 


View larger version (175K):
[in this window]
[in a new window]
  		Figure 11. Immunohistochemical staining with anti-kappa light chain is present in essentially all of the cells.

 

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?
Related Image Bank Image Sets logo
Multiple Myeloma
Peter Maslak
ASH Image Bank 2001 2001: 100211. [Full Text]

Multiple Myeloma
Peter Maslak
ASH Image Bank 2003 2003: 100632. [Full Text]

Multiple Myeloma
Peter Maslak
ASH Image Bank 2003 2003: 100672. [Full Text]

Multiple Myeloma
Peter Maslak
ASH Image Bank 2004 2004: 101113. [Full Text]

Multiple Myeloma
Peter Maslak
ASH Image Bank 2004 2004: 101227. [Full Text]

Normal Plasma Cell Distribution Along Bone Marrow Sinusoid
Calvino Ka-Wing Cheng
ASH Image Bank 2006 2006: 600034. [Full Text]

Extramedullary plasmacytomas
Margriet H. Wobbes and René van der Griend
ASH Image Bank 2008 2008: 800042. [Full Text]



Related ASH-SAP Chapter:space logo
Chapter 13: Plasma cell dyscrasias

This Article
Right arrow Figures Only
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new content in the Image Bank
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lazarchick, J.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Lazarchick, J.
Related Collections
Right arrow B-Cell Neoplasms
Right arrow Related ASH-SAP Chapter
Right arrowRelated Image Bank Image Sets
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

HOME HELP FEEDBACK SEARCH
Copyright © 2005 by the American Society of Hematology.