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Homozygous Hemoglobin C Disease

View larger version (164K): [in this window] [in a new window]   Figure 1. Peripheral smear from an 18 year old Black female who had a routine CBC performed as part of her prenatal laboratory studies. Her hemoglobin was 11.5 g/dL and her RBC indices were normal. The most striking finding on the smear is the presence of numerous target cells. In addition, there are crystal-like structures present in several RBCs and a few dense microspherocytes.

View larger version (99K): [in this window] [in a new window]   Figure 2. The crystal-like inclusions are more evident at higher magnification of the previous image. A classical "Washington monument" crystal typical of hemoglobin C crystal is present. Several other crystal configurations can also be seen, one rhomboid and the other appearing bi-lobed and extruding from an RBC.

View larger version (155K): [in this window] [in a new window]   Figure 3. The "Washington monument" and rhomboid-shaped crystalline structures are shown. Note that essentially all the RBCs are target cells.

View larger version (154K): [in this window] [in a new window]   Figure 4. In addition to the RBC abnormalities already described, dense microspherocytes can be seen in this view and are typical in homozygous hemoglobin C disease.

View larger version (115K): [in this window] [in a new window]   Figure 5. The microspherocyte is shown at a higher magnification of the previous image.

View larger version (152K): [in this window] [in a new window]   Figure 6. An intact RBC with an eccentrically placed hemoglobin C crystal is noted in the center of the image.

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This Article Figures Only Services Similar articles in this journal Alert me to new content in the Image Bank Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Lazarchick, J. Search for Related Content PubMed Articles by Lazarchick, J. Related Collections Hemolytic Disorders Related ASH-SAP Chapter Related Image Bank Image Sets Social Bookmarking                   What's this?