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ASH Image Bank (2007); doi:10.1182/ashimagebank-2007-7-00001
Copyright © 2007 by the American Society of Hematology.
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Sézary Cells

Julia Braza, M.D., M.S.


Figure 1
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  		Figure 1. This low power micrograph is a "thick prep" of a peripheral blood smear of a patient with mycosis fungoides, and contains two Sézary cells (arrows). Sézary cells are lymphoid cells with prominently folded, also known as, "cerebriform" nuclei. In this figure, these cells are 2-3 times larger than the surrounding lymphocytes. Sézary syndrome is characterized by extensive skin involvement, along with lymphadenopathy, splenomegaly and leukemic picture.

 

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  		Figure 2. This Sézary cell has the characteristic convoluted nuclear membrane, without a prominent nucleolus, and hyperchromatic chromatin. The cytoplasm is light blue-grey in color, and in some cases, may contain vacuoles.

 

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Sezary syndrome - peripheral blood
Peter Maslak
ASH Image Bank 2008 2008: 800045. [Full Text]




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Copyright © 2007 by the American Society of Hematology.