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Dohle Bodies in the May-Hegglin Anomaly

View larger version (130K): [in this window] [in a new window]   Figure 1. May-Hegglin anomaly is an autosomal dominant disorder characterized by: prominent Dohle bodies in granulocytic cells, poorly granulated giant platelets, and variable thombocytopenia that may cause purpura. In this figure, a neutrophil contains multiple prominent, light blue, round Dohle bodies, which are intracytoplasmic inclusions that consist of RNA.

View larger version (133K): [in this window] [in a new window]   Figure 2. A giant platelet accompanies the neutrophil in this figure. The finding of large, well-stained inclusions in non-toxic neutrophils plus the presence of giant platelets is pathognomonic of the May-Hegglin anomaly. The Dohle body in this neutrophil is oval in shape, and located between the nuclear lobes.

View larger version (127K): [in this window] [in a new window]   Figure 3. Dohle bodies may also be found in infection, where they tend to be smaller in size, and usually occur peripherally in the neutrophil, as opposed to in the May-Hegglin anomaly. Toxic granules and cytoplasmic vaculoles in the neutrophils are also seen in infection, and not in May-Hegglin anomaly.

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This Article Figures Only Services Similar articles in this journal Alert me to new content in the Image Bank Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Braza, J. Search for Related Content PubMed Articles by Braza, J. Related Collections Phagocytic disorders - Chediak-Higashi, Pelger-Huet, May-Hegglin Related ASH-SAP Chapter Related Image Bank Image Sets Social Bookmarking                   What's this?