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ASH Image Bank (2007); doi:10.1182/ashimagebank-2007-6-00057
Copyright © 2007 by the American Society of Hematology.
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Atlas Image Set

Variations on Pelger-Huet Anomoly

John Lazarchick, M.D.


Figure 1
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Figure 1. Two hyposegmented neutrophils are shown. The cytoplasmic granularity appears normal in these cells. These cells have the appearance of bands but represent a variation of the Pelger-Huett anomaly. Note the more deeply indented nucleus in the lower lower neutrophil and the irregular nuclear contour of the cell above it. Two normal lymphocytes are also shown.

 

Figure 2
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Figure 2. A higher magnification of a single cell from the previous image is shown.

 

Figure 3
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Figure 3. The three Pelger-Huet cells in this view show more rounded nuclear contours with mature chromatin and normal cytoplasmic granularity.

 

Figure 4
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Figure 4. Two Pelger-Huet cells are shown, both exhibiting irregular nuclear contours with slight indentations, mature chromatin, and granular cytoplasm.

 

Figure 5
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Figure 5. The Pelger-Huet cell in this view has a slightly indented nucleus without evidence of lobation.

 

Figure 6
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Figure 6. Although the filamentous segment connecting the two lobes of the Pelger-Huet cell shown is not apparent, this cell has the typical pince-nez form of nucleus characteristic of the Pelger-Huet anomoly.

 

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Related ASH Education Book Article logo
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Related ASH-SAP Chapter:space logo
Chapter 7: Myeloid disorders

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PubMed
Right arrow Articles by Lazarchick, J.
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Right arrow Pelger-Huet anomaly - other constitutional morphologic anomalies/disorders
Right arrow Related ASH-SAP Chapter
Right arrowRelated Image Bank Image Sets
Right arrowRelated ASH Education Book Article
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Copyright © 2007 by the American Society of Hematology.