ASH Image Bank
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ASH Image Bank (2007);doi: 10.1182/ashimagebank-2007-7-00013
Copyright © 2008 by the American Society of Hematology.
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Figure 3


Figure 3. This image best illustrates the difference between Pappenheimer bodies and Howell-Jolly bodies. The large arrow depicts a RBC with a Howell-Jolly body. Note: this is a single round dense structure with a regular border, as opposed to the Pappenheimer bodies (small arrow), which are frequently multiple inclusions with irregular borders. Howell-Jolly bodies are fragments of DNA and typically seen in the peripheral smears of individuals with sickle cell disease following auto-splenectomy. A nucleated RBS is also present in this view.





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Copyright © 2008 by the American Society of Hematology.