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Basophilic Stippling

View larger version (131K): [in this window] [in a new window]   Figure 1. A peripheral smear from a 3-year-old who presented with a hemoglobin of 9.5 g/dl is shown. Variable-sized multiple basophilic inclusions are present in a number of the RBCs, most evident in the polychromatophilic erythrocytes.

View larger version (128K): [in this window] [in a new window]   Figure 2. In this view, RBCs with fine (bottom left and bottom center) or coarse stippling (center) can be seen. The stippled inclusions are composed of RNA and represent aggregates of ribosomes.

View larger version (123K): [in this window] [in a new window]   Figure 3. Coarse dense basophilic stippling of several RBCs is shown in this view. Basophilic stippling can be seen in a variety of hematologic disorders including the thalassemias; heavy metal poisoning, particularly lead or arsenicals; dyserythropoietic anemias; megaloblastic anemia; and pyrimidine 5'-nucleotidase deficiency.

View larger version (82K): [in this window] [in a new window]   Figure 4. This view best illustrates the spectrum of stippling noted in this patient with cells containing either fine or coarse inclusions and with one RBC showing dense aggregates. The final diagnosis in this child was chronic lead poisoning caused by ingestion of paint chip fragments.

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This Article Figures Only Services Similar articles in this journal Alert me to new content in the Image Bank Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Lazarchick, J. Search for Related Content PubMed Articles by Lazarchick, J. Related Collections Iron and Blood Loss Related ASH-SAP Chapter Related Image Bank Image Sets Social Bookmarking                   What's this?