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Hereditary pyropoikilocytosis

View larger version (69K): [in this window] [in a new window]   Figure 1. This peripheral blood smear is from a 22-year-old female who presented to the emergency department with right upper quadrant pain. The CBC was remarkable for a microcytic, hypochromic anemia (hemoglobin = 9.6 g/dL; MCV = 68.2 fL and MCH = 22.1 pg), normal WBC count, and a platelet count of 153K. Examination of the peripheral blood film showed marked anisocytosis with numerous rod-shaped elliptocytes and bizarre red cell forms.

View larger version (56K): [in this window] [in a new window]   Figure 2. 22-year-old female with right upper quadrant pain. The red cells also appear hypochromic with an increased central zone of pallor. Hereditary pyropoikilocytosis is a subtype of hereditary elliptocytosis in which a spectrin defect is combined with a spectrin deficiency. This entity is associated with chronic severe hemolytic anemia.

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This Article Figures Only Services Similar articles in this journal Alert me to new content in the Image Bank Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Lazarchick, J. Articles by Post, G. R Search for Related Content PubMed Articles by Lazarchick, J. Articles by Post, G. R Related Collections Hemolytic Disorders Related ASH-SAP Chapter Related Image Bank Image Sets Related ASH Education Book Article Social Bookmarking                   What's this?