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Hairy cell leukemia involving the spleen

View larger version (169K): [in this window] [in a new window]   Figure 1. Hairy cell leukemia involving the spleen is characterized by massive infiltration of the splenic red pulp by small to medium sized B cells with abundant pale cytoplasm. The image shown illustrates the pale appearance of the red pulp with distended sinuses containing numerous RBCs.

View larger version (189K): [in this window] [in a new window]   Figure 2. The lymphoid infiltrate consists primarily of monotonous small cells with pale cytoplasm. The RBC "lakes" are prominent in this view. Scattered leukemic cells can also be seen in these sinuses.

View larger version (178K): [in this window] [in a new window]   Figure 3. A higher magnification of the previous images shows the small to medium sized lymphocytic infiltrate more clearly. The cells are round to kidney-shaped with abundant clear cytoplasm giving the appearance of "fried eggs." The sinusoid are filled with RBCs characteristic of this disorder.

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This Article Figures Only Services Similar articles in this journal Alert me to new content in the Image Bank Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Lazarchick, J. Search for Related Content PubMed Articles by Lazarchick, J. Related Collections B-Cell Neoplasms Related ASH-SAP Chapter Related Image Bank Image Sets Related ASH Education Book Article Social Bookmarking                   What's this?