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ASH Image Bank (2008); doi:10.1182/ashimagebank-2008-8-00137
Copyright © 2008 by the American Society of Hematology.
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Atlas Image Set

Lymphocyte inclusion in Chediak-Higashi syndrome

John Lazarchick, M.D.


Figure 1
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Figure 1. A single large reddish granule is noted in the cytoplasm of this patient who has a diagnosis of Chediak-Higashi syndrome. These patients are at increased risk for infection and have decrease NK cell function and impaired platelet function.

 

Figure 2
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Figure 2. This image is included to emphasize that the cytoplasmic inclusions which are typically noted in the neutrophils, monocytes and lymphocytes may not be seen in all cells of the same lineage on a patient’s peripheral smear. In this case, only one of the two lymphocytes present in this view has the characteristic inclusion.

 

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Related ASH-SAP Chapter:space logo
Chapter 7: Myeloid disorders

This Article
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PubMed
Right arrow Articles by Lazarchick, J.
Related Collections
Right arrow Phagocytic disorders - Chediak-Higashi, Pelger-Huet, May-Hegglin
Right arrow Related ASH-SAP Chapter
Right arrowRelated Image Bank Image Sets
Right arrowRelated ASH Education Book Article
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Copyright © 2008 by the American Society of Hematology.