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Marrow involvement in systemic mastocytosis

View larger version (177K): [in this window] [in a new window]   Figure 1. A low-power view of a bone marrow biopsy of a patient with systemic mastocytosis is shown. The marrow is markedly hypercellular with pale appearing patch-like infiltrates noted between areas of normal hematopoiesis. The infiltrates are in a paratrabecular and perivascualr distribution.

View larger version (163K): [in this window] [in a new window]   Figure 2. The distribution of the infiltrate is more readily appreciated in this view, extending from the paratrabecular location downward surrounding the vessel. Eosinophils appear to form a border border to the infiltrate in this view.

View larger version (147K): [in this window] [in a new window]   Figure 3. The cells within the infiltrate show abundant eosinophilic cytoplasm and many of the cells have an irregular shaped nucleus. Basophilic granules are not apparent. Numerous eosinophils can be seen at border of the lesion.

View larger version (162K): [in this window] [in a new window]   Figure 4. These features are even more apparent at the magnification shown here. Note the mast cells extend into the eosinophil border area.

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This Article Figures Only Services Similar articles in this journal Alert me to new content in the Image Bank Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Lazarchick, J. Search for Related Content PubMed Articles by Lazarchick, J. Related Collections Mast Cell Disease Related ASH-SAP Chapter Related Image Bank Image Sets Related ASH Education Book Article Social Bookmarking                   What's this?