Figure 1. Patient is a 43-year-old male with HIV/AIDS who presented to the ER with fever. Sputum, urine, and blood cultures for an infection were all negative. A bone marrow biopsy were performed to rule out a lymphoproliferative disorder. The marrow was cellular with a left shifted myeloid series. The erythoid series progressed through full maturation sequence and megakaryocytes appeared normal in number and morphology. No lymphoid infiltrate or granulomatous lesion was identified.
Figure 3. On closer examination, there appears to be a marked increase in plasma cells without evidence of atypia as illustrated in this image. Many of these cells appear to be perivascular inlocation. However, there is no associated lymphocyte population, as is normally seen around blood vessels.
Figure 4. A CD138 immunohistochemical stain shows the marked plasmacytosis in this marrow. This antibody reacts with syndecan 1 present on the cytoplasmic membrane of plasma cells.
Figure 7. This image illustrates in situ hybridization for light. These results are consistent with non-clonal plasmacytosis that can be seen in patient with HIV/AIDS.
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light chain was performed on the biopsy. Kappa light is shown in this image.