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T-cell prolymphocytic leukemia

View larger version (140K): [in this window] [in a new window]   Figure 1. Low-power view of a peripheral smear from a patient with T-cell prolymphocytic leukemia. Note the monotonous population of intermediate-sized cells with agranular basophilic cytoplasm and large irregularly shaped nuclei. In addition basket or smudge cells are readily seen.

View larger version (119K): [in this window] [in a new window]   Figure 2. The cellular features of typical cells seen in T-cell PLL are more evident in this view. Two normal sized lymphocytes can be seen in the low section of the image. The cytoplasm of the larger cells is deeply basophilic and agranular. The nuclear contours of these cells range from round to irregular but cleaving is not present. Single prominent nucleolus is evident in most cells. Several basket/smudge cells are also noted.

View larger version (127K): [in this window] [in a new window]   Figure 3. A high-magnification view of the previous image is shown. Note the single prominent nucleolus in two of these cells and multiple small nucleoli in the other malignant cell.

View larger version (118K): [in this window] [in a new window]   Figure 4. Another high-magnification view of the malignant T-cell prolymphocytes is shown. The cytoplasm in each cell is basophilic. There is a suggestion of cytoplasmic vacuolization in the upper cell and a hof in the lower cell. The nuclear contours are irregular, and the chromatin is clumped. Two nucleoli are noted in the cupper cell but only one in lower cell. On flow cytometry, these cells showed a normal T-cell immunophenotype. However, in other cases of T-cell PLL coexpression, CD4 and 8 may be noted. This case demonstrated an inversion of chromosome 14, a finding seen in 80% of the cases.

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This Article Figures Only Services Similar articles in this journal Alert me to new content in the Image Bank Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Lazarchick, J. Search for Related Content PubMed Articles by Lazarchick, J. Related Collections T-Cell and NK-Cell Neoplasms Related ASH-SAP Chapter Related Image Bank Image Sets Related ASH Education Book Article Social Bookmarking                   What's this?